MST3K: Favorite/least favorite female character.
Pearl Forrester for both. (That said, Pearl and Gypsy are the only two constant female characters, and Gypsy is just "there" for me.) I couldn't stand Pearl during the Comedy Central years. I think the team genuinely thought they were writing really funny stuff during that time, but Pearl and her interaction with Dr. Forrester drove me away from the show. I didn't come back until sometime in Season 8 or 9 (not sure now), whereupon I decided Pearl was OK, but Observer and Bobo were hit or miss.
Pearl became a better villain in the SciFi years ("I think [I'm evil] because I'm filled with hate, that might have something to do with it") and actually got pretty funny as time went on.